‘Dementia’ Articles

Dementia and Autoimmunity: What You Need to Know to Make an Accurate Diagnosis

Alzheimer disease, frontotemporal dementia (FTD), and Creutzfeldt-Jakob disease (CJD) are among the most recognized forms of dementia.  Each of these neurodegenerative forms has distinct features. However, they also have overlapping characteristics, many of which are similar to those of non-neurodegenerative dementia, such as those with Read more

  • June 30, 2015
  • 12:06pm EST

TDP-43: The Third Protein Linked to Alzheimer’s Disease

The TDP-43 protein (transactive response DNA binding protein), encoded by the TARDBP gene, plays an important role in regulating transcriptional repression, RNA metabolism and gene splicing under normal conditions 1. Typically, TDP-43 is continually shuttled between the nucleus and cytoplasm to perform its functions 2.  Read more

  • March 24, 2015
  • 05:30am EST

Connecting the Dots Between Tau Dysfunction and Neurodegeneration

Tauopathies are a group of devastating – and often fatal – neurodegenerative diseases characterized by insoluble filamentous deposits of abnormally phosphorylated tau protein within neurons and glia. Accumulation of hyperphosphorylated tau in these regions causes the formation of neurofibrillary tangles that are characteristic of many Read more

  • September 18, 2014
  • 09:45am EST

Dementia: Confirming the Diagnosis

The number of Americans with dementia from Alzheimer’s disease (AD) is expected to triple over the next 40 years. That forecast from a recent study1 is simply the latest to confirm that, as America ages, we will be faced with unprecedented numbers of patients with Read more

  • June 26, 2013
  • 06:00am EST